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These responses can precede neurodegeneration and are significantly ameliorated in STING-knockout models, indicating that cGASSTING activation plays a pivotal role in -syn-induced neuroinflammation [170, 171]

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TGF- is widely recognized for its potent ability to induce the epithelialmesenchymal transition in various cell types, including hepatocytes

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Back to Journals Drug Design, Development and Therapy Volume 19 Chinese Herbal Medicine in Hypoxic Pulmonary Hypertension Treatment: Mechanisms, Progress, and Future Directions Authors Wang X, Deng T, Zhu H , Peng J, Liang J, Zhong S, Yao C, Jin G Received 3 April 2025 Accepted for publication 28 August 2025 Published 15 September 2025 Volume 2025:19 Pages 82658294 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Mariana Carmen Chifiriuc Xunkai Wang, 1 3, * Tang Deng, 1, 4, * Houfan Zhu, 1 3, * Jin Peng, 1 3 Jinxi Liang, 5 Shijie Zhong, 1 3 Chen Yao, 4 Guiyun Jin 1 3 1 Department of Interventional Radiology and Vascular Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou, Peoples Republic of China