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It stimulates glucose uptake, increases fat metabolism, and boosts mitochondrial function

10.16781/j.0258-879x.2018.05.0573 108 ZengP.LiJ.ChenY.ZhangL

Another strategy to extend levodopa efficacy involves inhibiting catechol-O-methyltransferase, an enzyme responsible for both peripheral levodopa degradation and central dopamine breakdown

Moriguchi et al., 2019), a major strength of the multimodal neuroimaging approach of TIGER is that it allows us to integrate information from multiple neuroimaging modalities (e.g., fMRI, diffusion MRI) to enable us to reconcile these potential discrepancies in the literature and gain a more precise understanding of glutamatergic abnormalities underlying MDD (Salvadore and Zarate, 2010

Similar to FSP1, GCH1 expression is significantly correlated with ferroptosis resistance, and GCH1 inhibition can enhance erastin-induced ferroptosis by promoting ferritinophagy, suggesting that the GCH1/BH4/DHFR system might serve as a novel ferroptosis defensive mechanism and a promising therapeutic target[34]

After that, pertinent research has progressively surfaced [94]