chac1 er stress glutathione degradation Frontiers Glutathione-specific gamma–glutamylcyclotransferase 1 (CHAC1) increases
Glutathione specific gammaglutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Science Translational Medicine Regulation of ChaC1. Oxidative and ER stress, and viral infection Download Scientific Diagram This figure illustrates the interactions and regulatory mechanisms Download Scientific Diagram ChaC1 based drug screenings identify a synergistic lethal effect of auranofin and proteasome inhibitors in hepatocellular carcinoma cells Cell Death Discovery Dysregulated lipids homeostasis disrupts CHAC1 mediated ferroptosis driving fibroblast growth factor receptor tyrosine kinase inhibitor AZD4547 resistance in gastric cancer ScienceDirect CHAC1 degradation of glutathione enhances cystine starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2 eIF2 ATF4 pathway Oncotarget
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