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Hyaluronic acidglutathione (HAGSH) scaffolds are next-generation redox-responsive biomaterials that actively support tissue repair rather than serving as passive dressings

Besides, vitamin E is another physiologically essential antioxidant able to mitigate the toxicity arising from lipid peroxides [274]

Biomedicines 12, 1131

Dosing efficacy as well as circulating levels of GSH-T, the ratio of reduced to oxidized glutathione (GSH-F:GSSG) and concentrations of malondialdehyde (MDA), a lipid peroxide marker of oxidative stress, as well as that of total cysteine, an indicator of oxidation of reduced cysteine to oxidized forms of cysteine, were assessed as secondary efficacy outcomes

[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Elliott S.P

These results are consistent with reports that glycosylation (glucose, galactose, arabinose, rhamnose) and positional changes of the hydroxyl groups modulate flavonoid bioactivity and pharmacological properties (Reference Szeja, Grynkiewicz and Rusin50,Reference Domnguez-Avila, Gonzlez-Aguilar and Alvarez-Parrilla54)