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tricolor , as a functional osmolyte and antioxidant for adjustment of osmotic stress and ROS detoxification in A

This has been demonstrated in a variety of cancer cell lines, tumor xenografts, spontaneous mouse tumors in transgenic animals and human tumor samples (references in Table 1 )

However, in the presence of excess iron within the cell, H 2 O 2 triggers the Fenton reaction under the catalysis of ferrous iron (Fe 2+ ), leading to the production of -OH (Shi et al., 2023)

However, a more detailed understanding of the expression profile and reliance of these transporters is required

The global sensitivity analysis also confirmed the importance of the redox cycle between SQ . and H 2 Q ( R 4 ), showing that the reverse rate constant, k m4 (SQ . reformation), was the second most sensitive (main interactions) with respect to model OCR and therefore ROS production, suggesting auto-oxidation is an essential part of the doxorubicin redox mechanism