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AMP research exploits their: Broad-spectrum bactericidal activity via membrane perturbation (colloido-osmotic mechanism, pore formation) Low resistance to bacterial selection (physical mechanism, little subject to mutation) Potential as antibiotic substitute in multi-resistance context Immunomodulatory activity : LL-37 stimulates leukocyte migration, neovascularisation, reepithelialisation In preclinical research, new-generation synthetic antimicrobial peptides (derivatives of magainin, indolicidin, protegrins) are tested on infected wound models

Int Immunopharmacol 89:107088 Wang T-Y, Chen J-X (2019) Effects of curcumin on vessel formation insight into the pro-and antiangiogenesis of curcumin

While TUDCA is generally well-tolerated and backed by human studies in specific contexts (e.g., liver disease, insulin sensitivity), there are several populations who should avoid it

doi: 10.1016/j.jtemb.2022.127047 90 ZimmermannMBZederCChaoukiNSaadATorresaniTHurrellRF

You may hear a slight buzzing or humming from the device