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Both trials met their primary and all prespecified secondary endpoints, including a statistically significant reduction in acute pancreatitis events a potentially fatal complication of severe hypertriglyceridemia

Naeimi RA, Talebpour Amiri F, Khalatbary AR, Ghasemi A, Zargari M, Ghesemi M, Hosseinimehr SJ

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Disruption of CTCF/cohesin-mediated high-order chromatin structures by DNA methylation downregulates PTGS2 expression

Acute complete depletion may rapidly amplify oxidative stress and cell injury, whereas more gradual depletion appears to allow for more selective redox remodeling without overwhelming stress responses, although further studies including comprehensive transcriptomic and epigenomic analyses will be necessary to dissect the differential regulatory networks altered by different modes of GSH depletion

Cell detection was conducted using QuPaths built-in Positive cell detection