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Mei J, Xu D, Wang L, Kong L, Liu Q, Li Q, et al

10.1007/pl00000319 55 Sanchez-MendozaM

These data strongly support the conclusion that isoxazole 1 inhibits Cn Acs1

Similarly, MRTX849 treatment decreased intratumoural immunosuppressive myeloid-derived suppressor cells and M2-polarised macrophages and increased immune-promoting M1-polarised macrophages, dendritic cells, and CD4 + and NKT cells in KRAS (G12C) tumours by altering the expression of tumour RNA and protein implicated in the presentation of tumour antigens or mediating an immunosuppressive TME 204

In contrast to ASXL1 1-591 , ASXL1 1-645 simultaneously and independently interacts with BRD4 and the H3K4-specific methyltransferases MLL3/4, whereas the shorter variant is lacking the MLL3/4-binding site and interacts only with BRD4