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Accumulated Ang II is responsible for the overstimulation of its type-I receptor which is associated with various pathological conditions [16]

Topical application of PEPITEM not only reduced local inflammation but also had systemic effects, such as reducing disease-related splenomegaly and limiting the expansion of CD4+, CD8+, Th1, and Th17 T-cell populations in the spleen

J Biol Chem 276: 77627768 Frand AR, Kaiser CA (1998) The ERO1 gene of yeast is required for oxidation of protein dithiols in the endoplasmic reticulum

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These different miRNA expressions suggest specific functional significance in fine-tuning the target mRNA levels at various stages of the APAP toxicity