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These findings indicate that oral glycine supplementation corrected glycine deficiency in individuals with severe obesity, which in turn increased flux through the glycine conjugation pathway and the one-carbon cycle

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Macrophages (Ms) and neutrophils are crucial cell types in the generation of effective immune responses, particularly in response to bacterial infection

Therefore, therapies targeting ATF4 must balance the anti-inflammatory outcomes with host immune protection (199)

Homogenates were centrifuged at 20,000 x g for 20 min