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Role of MEK inhibition in improving anti-tumor responses in xenograft models of BRAF-mutated metastatic colorectal cancer

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The researchers concluded that EGCg's rapid mitigation of systemic inflammation and oxidative stress not only aided in acute recovery but also highlighted its potential in supporting the body against the long-term fibrotic and neurological damage that precipitates Long COVID

The activated state correlated with elevated transcription of the pro-inflammatory cytokine IL-1, indicating that MP exposure triggers microglial activation and subsequent hypersecretion of inflammatory mediators, thereby accelerating neuronal damage 31

Its primary mechanism involves upregulating Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) two proteins essential for neuronal health, plasticity, and survival