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Sirtori CR, Calabresi L, Franceschini G, Baldassarre D, Amato M, Johansson J, Salvetti M, Monteduro C, Zulli R, Muiesan ML, Agabiti-Rosei E

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4.6.8 Mitochondrial Function and Energy Metabolism Energy metabolism is dysregulated early in the course of ALS as a result of decreased appetite, increased energy expenditure, and hypothalamic dysfunction, among other complex factors [295,296,297,298,299]

The number of these cells increases in stress situations related to infections, inflammation, organ injury as well as after strenuous exercise