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Intestinal barrier dysfunction, termed leaky gut, is characterized by increased translocation of bacterial metabolites and endotoxins (particularly LPS) into systemic circulation (87)

With the progress of technology, the accuracy of extracorporeal radiotherapy is getting higher and higher, which allows radiotherapy to be applied to patients with HCC ( in vivo , both single-dose and fractionated irradiation promoted the metastasis of HCC cells 2060 days after irradiation

However, differences in the sensitivity of tumor cells to anticancer drugs also occur because of changes in the pathways that mediate cell death and survival

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