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Tetramethylpyrazine (Ligustrazine), the principal active component of Ligusticum chuanxiong Hort., has been demonstrated by Zheng et al

In a study of hyperthyroid mice supplemented with T3, Feng et al

What makes it special is what it doesn't do: unlike other peptides in its class, it doesn't raise cortisol (your stress hormone) or prolactin, even at doses 200 times higher than needed