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This complex system comprises innate and adaptive immunity, jointly forming the bodys first and second lines of defense against infections and disease ( The immunomodulatory effects of exercise depend on exercise intensity and the total exercise workload ( In this context, the present study aims to review the existing literature to analyze the effects of different types of exercise workloads on immune cell function ( Figure 1 ), cytokine profiles (e.g., IL6, TNF, IL10), mucosal immunity, and immunoglobulin production