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Among individuals with CSF and plasma data, AD cases corresponded to those with a diagnosis of dementia of the Alzheimers type (DAT) using criteria equivalent to the National Institute of Neurological and Communication Disorders and Stroke-Alzheimers Disease and Related Disorders Association for probable AD 58 , and AD severity was determined using the Clinical Dementia Rating (CDR) 59 at the time of lumbar puncture (for CSF samples) or blood draw (for plasma samples)

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Clinical and pathological patterns related to natural history