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Superoxide dismutase (SOD) levels were measured using chemiluminescence assay, malondialdehyde (MDA) levels via radioimmunoassay, and glutathione peroxidase (GSH-Px) levels via colorimetric assay

Oleuropein regulates bile acid metabolism via modulating the gut microbiota, thereby alleviating DSS-induced ulcerative colitis in mice

The procedure is a stereotactic neurosurgical operation under general anaesthesia: A small burr hole is made in the skull Under stereotactic guidance, a fine needle is advanced into the putamen (a deep brain structure) Progenitor cells are deposited at multiple sites in both putamina (bilateral transplantation) Phase I/II results (Sawamoto et al., Nature 2025) Patients: 7 (ages 5069) with idiopathic Parkinsons disease responsive to levodopa Follow-up: 24 months Serious adverse events: None Mildtomoderate adverse events: 73 total Efficacy (among 6 patients evaluable for efficacy): MDS-UPDRS Part III improved in the OFF state in 4 of 6 patients MDS-UPDRS Part III improved in the ON state in 5 of 6 patients Mean OFF-state improvement: 9.5 points (20.4%) Mean ON-state improvement: 4.3 points (35.7%) Hoehn-Yahr stage improved in 4 of 7 patients Imaging: F-DOPA influx rate constant (K) increased by 44.7% in the putamen, with greater increases in the high-dose group direct evidence that grafted cells survived and produced dopamine No graft overgrowth on MRI Can international patients get Amchepry in Japan

doi: 10.1111/bph.12746

Second, GSNO may help maintain or restore endothelium derived NO signaling, preserving vasorelaxation, minimizing reperfusion-associated vasoconstriction, and supporting coronary perfusion