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Upon binding to double-stranded DNA, cGAS catalyzes the synthesis of cyclic dinucleotide GMP-AMP (cGAMP) that binds to STING, which in turn recruits tank-binding kinase 1 that activates interferon regulatory factor 3, resulting in type I IFN production, as well as NF-B, leading to the expression of proinflammatory cytokines (Victorelli et al., 2023

Mol Neurobiol 53:34623476 Shaughnessy LM, Swanson JA (2007) The role of the activated macrophage in clearing Listeria monocytogenes infection

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