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However, the increased total amount of PUFA increases their susceptibility to lipid peroxidation

Naz S, Imran M, Rauf A, Orhan I, Shariati MA, Haq I, Iqra Y, Shahbaz M, Qaisrani T, Shah Z, Plygun S, Heydari M (2019) Chrysin: pharmacological and therapeutic properties

TB-500 has a longer plasma half-life of approximately 2-3 hours due to its larger molecular size (~4963 g/mol) and slower clearance

10.1016/j.cell.2022.12.024 31 MynarskaE.WasiakJ.GajewskaA.SteG.JasiskaJ.RyszJ.et al (2024)

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Galunisertib was evaluated in an open-label phase 2 clinical trial in patients with HCC and had a reasonable safety profile, while lower AFP and TGF-1 levels were associated with longer survival