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Any temperature excursion above 8C for liquid formulations or exposure to light accelerates oxidation, converting active GSH to inactive glutathione disulfide (GSSG)

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Newly recognized roles of factor XIII in thrombosis

Not approved by regulatory agencies such as the FDA for clinical or human use

This accumulation results in mitochondrial dysfunction, an elevation in ROS, and structural changes due to macromolecular cross-linking

Despite the antitumor effect of erastin, evidence has also shown that iron concentration and macrophage polarization in the tumor microenvironment promote the resistance of ovarian cancer cells to erastin-induced ferroptosis