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HDAC6 inhibition prevents TNF--induced caspase 3 activation in lung endothelial cell and maintains cell-cell junctions

Under hypoxia or mitochondrial dysfunction, -KG can be converted to citrate by Isocitrate dehydrogenase (IDH 2) catalyzed carboxylation reaction, which is used for the synthesis of amino acids and fatty acids and the production of reducing agent NADPH

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Cell 83 , 37873800 e9 (2023)

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An overdose is very unlikely if you consume this compound exclusively from whole foods