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Briefly, protein aggregates should bind to the HSP70-HSP40 complex and p97, a powerful ATPase, at the same time and then be recognized by TAX1BP1 and routed into aggrephagosomes (Krner et al., 2025)

doi:10.1523/JNEUROSCI.0922-10.2010 pmid:20445064 Schuldiner O, Yaron A (2015) Mechanisms of developmental neurite pruning

The upregulation of COX2 in human degenerated nucleus pulposus: the association of inflammation with intervertebral disc degeneration

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