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Research into BPC-157 has accumulated over three decades, with studies examining its effects on tendons, ligaments, muscles, bones, the gastrointestinal tract, blood vessels, and even neurological tissue

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Although the SPH domain alone cannot activate c-MET, mutations that disrupting the interaction between HGF-SPH and c-MET-SEMA significantly reduce HGF-induced c-MET activation, validating the functional importance of this interaction 15

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