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Single-cell sequencing technologies have been used to discern ASC heterogeneity (Fig

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Laboratory investigations reveal that 5-amino-1MQ suppresses lipogenesis in adipocytes with an EC of 30 M, mechanistically achieved through restoration of cellular NAD+/SAM ratios that favor lipolysis over lipid storage

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However, the Canadian study included only patients aged 65 years and older, and the other study was conducted in the United Kingdom