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10.1146/annurev-biochem-040320-104628 Summary Keywords cadmium, mercury, nickel, manganese, element-specific detection, separation mechanism, mechanism of chronic toxicity Citation Gailer J (2026) Tailoring LC approaches to address the chemical biology of toxic metals in humans

For example, in hepatocellular carcinoma (HCC), ferroptosis serves as a tumor-suppressive mechanism in early stages but becomes dysregulated in advanced disease, suggesting that dynamic modulation may be necessary during different phases of neurodegeneration

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The gut metabolite indole-3-propionic acid activates ERK1 to restore social function and hippocampal inhibitory synaptic transmission in a 16p11.2 microdeletion mouse model

Analytical size exclusion chromatography (SEC) Analytical SEC was carried out using a 10/300 GL Superose 6 Increase column (Cytiva) equilibrated in 25 mM HEPES, pH 7.5, 500 mM NaCl, 0.5 mM TCEP, and 5% glycerol