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Study 2: Selective Small-Molecule Inhibitors (including 5-Amino-1MQ) A selective, membrane-permeable NNMT inhibitor series decreased intracellular 1-MNA, increased NAD and SAM, suppressed adipocyte lipogenesis, and reversed high-fat-diet obesity in mice

V1aR knockout models, which lack the receptor on which AVP exerts its vasoconstrictive abilities, are prone to obesity [35]