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Nrf2 silencing abrogated Met- and L-car-induced upregulation of BAT-related genes in mouse adipocytes To decipher the role of Nrf2/HO-1 signaling in Met and L-car-induced browning of adipocytes, 3T3-L1 cells were induced to differentiate into mature adipocytes following Nrf2 silencing

A state of catabolism precipitated by any stressor can contribute to exacerbation of the underlying metabolic decompensation and promote worsening metabolic acidosis, ketosis, and also possibly hyperammonemia

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The combined effects of these mechanisms in COPD result in the secretion of inflammatory mediators, reduced antioxidants, degradation of elastin, and fibroblast generation, resulting in airway remodeling, irreversible airflow limitation, and a series of symptoms (Fig

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Thus, motor performance fatigue can be described as a decrease in the maximal voluntary force production capacity of the neuromuscular system, which is determined by neural and muscular factors