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Cycle smart: many practitioners recommend 812 weeks on, followed by a 8-12 week break to allow natural remodeling before restarting

Research in aging mouse models shows that MOTS-c administration suppresses SASP markers and reduces the burden of senescent cells in metabolically active tissues [2]

No large human randomized controlled trial exists for either compound in any musculoskeletal use

BPC-157 is not FDA-approved as a finished drug and its human evidence base is still developing

Evidence Quality: Very High