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urinaria extract can induce apoptosis in Lewis cells and combat lung cancer through the mitochondria-related intrinsic pathway, with upregulation of caspase 3 expression and downregulation of Bcl-2 expression, all while demonstrating minimal toxicity to normal cells (Supplementary Table S4 summarizes the pharmacological activities of P

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One governance-focused industry analysis puts it directly: without Quality by Design (QbD) principles built into study design from the start, decentralization becomes fragmentation a patchwork of one-off systems per trial rather than a scalable, repeatable model

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