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This, however, does not mean that they do not have favorable or preventive effects against different pathologies, but it demonstrates that the food matrix is an important element to be considered in the therapeutic effects of polyphenols

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Central to this is the role of polyunsaturated fatty acids (PUFAs), which are instrumental in phospholipid peroxide accumulation [135]

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Additionally, the flox sites have differed across these transgenic lines [198], with some groups inserting loxP sites at exon 1 resulting in a frame-shift mutation [174], exon 2 resulting in a frame-shift mutation [68, 185], and exon 3 resulting in an in-frame deletion [177]

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