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All-trans retinoic acid All-trans retinoic acid (ATRA), a metabolic derivative of vitamin A in animals, is efficient in the treatment of APL with a complete remission rate of 9095% in patients [39]

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Because of the similarity in the pathomechanism of different SNHLs and the known DAergic [82], anti-apoptotic [24], anti-oxidant [25], neuroprotective [26] and immunmodulatory actions [27] of selegiline, we initiated a study on the effects of selegiline and its analogues on DA release from LOC terminals in the mouse cochlea and in an AGIHL mouse model

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