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No significant heterogeneity was found among RCTs in the diabetic subgroup (I 2 = 0%, P = 0.38), and thus fix-effects model was chosen

HDL-c increase was recorded as 12.92, 41.95, and 34.78%, whereas LDL-c decrease was noted as 47.12, 65.37, and 64.64% after LSHE at 50, 100 mg GAE Kg 1 or 50 mg Kg 1 Vit

Youth Innovation Program Team in Universities of Shandong Province, China (No

and YD9100002005 to H.Z.), CAS Project for Young Scientists in Basic Research (YSBR-013 to W.X.), CAS Collaborative Innovation Program of Hefei Science Center (2021HSC-CIP003 to W.X.), University Synergy Innovation Program of Anhui Province (GXXT-2022-033 to H.Z.), Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM (QYZD20230011 to W.X.) and Major Science and Technology Special Projects, Anhui Provincial Department of Science and Technology (202303a07020005 to W.X.)

Cells and supernatants were then collected by centrifugation

Physiological modeling of formulated and crystalline 3,3 -diindolylmethane pharmacokinetics following oral administration in mice