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After MALDI IMS analysis, spectra and images acquired from the oxaliplatin treated and untreated MCTS were analyzed by calculating co-localized and anti-correlated m/z values as well as using the ROC tool to find discriminating m/z signals

Intravenous administration was associated with an increased hepatic survival (14/21 vs

van der Heijden, Roderick C

Interim results from a phase 1/2 clinical trial of AAV-based GRN gene therapy (PR006) have demonstrated that one-time injection of PR006 into the cisterna magna is generally safe and well tolerated and increases CSF PGRN levels [216]