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Ethics declarations Ethics approval and consent to participate The clinical studies in this review were approved by the Western Institutional Review Board (IRB protocol #20201286, StudyID: STUDY00002547)

The development of a potentially life-threatening serotonin syndrome has been reported with SNRIs and SSRIs, including clomipramine hydrochloride capsules, alone but particularly with concomitant use of other serotonergic drugs (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St