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Efforts to enhance antioxidant properties through molecular modifications, using advanced technologies such as prodrug strategies, nanotechnology, polymer complexation, targeted delivery systems, or conversion into inhalable formulations, have yielded variable success

Proc Natl Acad Sci USA 102 , 1349613501 (2005)

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Med Gas Res 6:7984 Huang P, Chen S, Wang Y, Liu J, Yao Q, Huang Y, Li H, Zhu M, Wang S, Li L, Tang C, Tao Y, Yang G, Du J, Jin H (2015) Down-regulated CBS/H 2 S pathway is involved in high-salt-induced hypertension in Dahl rats

These findings can be explained by the interaction between membrane anchoring moieties, such as cholesterol and fatty acids present on the surface of LPNs, with the hydrophobic tail regions of phospholipids within the cell membrane 53

Our in vitro experiments strongly suggest that hydropersulfides are highly efficient in directly reducing radicals