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A key adaptive response is observed upon DNMT3A loss, in which compensatory hypertrophic signaling can restore metabolic and contractile function, demonstrating that its regulatory role is context-dependent and can be bypassed under stress

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Elevated RRM2 levels also correlate with MYCN expression levels and poorer survival outcomes in NB patients (47)

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For the cyanocobalamin component, while generally considered safe with few absolute contraindications, certain conditions warrant caution