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The two mechanisms are complementary and their combination produces a documented synergistic effect (Ionescu & Bhatt, Endocrine 2006)

Hypoxia also influences iron regulation by inactivating cytoplasmic prolyl hydroxylase domain (PHD) proteins, for which iron acts as a necessary cofactor

Based on the theory developed by Zalpoor et al

The region increasingly exports medicines and products to neighboring countries and other economies worldwide

In contrast, the lower chambers were supplemented with RPMI 1640 or McCoys 5 A medium supplemented with 15% FBS to detect tumor cell migration and invasion ability