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Inhibiting KMO effectively redirects metabolic flux toward KYNA production, alleviating neuropathological symptoms and inhibiting tumors in preclinical models ( In gliomas, the metabolite balance shifts toward neurotoxicity and tumor progression, with a decrease in protective metabolites and an increase in neurotoxic or oncogenic species ( Figure 3c ) (Moffett et al., 1993)le prognostic indicator (Krupa et al., 2025)

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