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Glutathiones role in this second phase is vital, it attaches to heavy metals, pollutants, and metabolic byproducts, making them water-soluble for easy excretion (NIH)

Smolarek TA, Higgins CV, Amacher DE: Metabolism and cytotoxicity of acetaminophen in hepatocyte cultures from rat, rabbit, dog, and monkey

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Alternative activation of macrophages is induced by IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergic, cellular and humoral responses to parasitic and selected pathogen infections

These kinases phosphorylate the membrane transporters (DAT, NET, SERT), leading to two outcomes: the transporters are either internalized into the cell (ceasing all reuptake function) or they undergo a conformational shift that causes them to operate in reverse