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Among these three, tirzepatide (dual agonist) is the newest generation

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Although the clinical practice guidelines did impact injection use, given the high costs of these injections and their questionable clinical efficacy , further interventions beyond publishing clinical practice guidelines are needed to encourage higher-value care for patients with knee osteoarthritis . Corticosteroid injections in the hip and knee: Not as safe as doctors think In October 2019, doctors published their study: Intra-articular Corticosteroid Injections in the Hip and Knee: Perhaps Not as Safe as We Thought? in the medical journal Radiology .( 7 )

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Tirzepatide does not directly stimulate fat cell breakdown

Son, K-B., Lee, T-J