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Iron is tightly controlled at the systemic and cellular levels to prevent iron overload and toxicity, which is associated with liver disease, diabetes, osteoporosis, heart disease, atherosclerosis, and neurodegenerative diseases (Galaris et al., 2019

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doi: 10.1016/j.it.2016.08.012 37 LaurenceATatoCMDavidsonTSKannoYChenZYaoZet al

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