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Treatment with dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase, increases pyruvate dehydrogenase activity and systolic blood pressure in 34 weeks old SHR and WKY rats 55

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Simultaneously, in comparison to traditional lung protective ventilation using low tidal volume, a combination of low tidal volume, recruitment maneuver, and high PEEP did not result in a reduction in ALI mortality, despite significantly improving their refractory hypoxemia [120]

Samples were then mixed with nitric acid 65% and heated at 80 C overnight in the same glass vials closed with a lid carrying a Teflon septum

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