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[56] Oxidative stress can cause DNA damage in neurons

Short and mild increases in IOP may induce reactive activation of Mller cells, astrocytes and microglia prior to significant RGC/axonal damage

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H.-C., Standaert, T., Alptekin, E., Spooner, T., & Paruchuri, V

The patient will be at the heart of everything the NHS does

4 Challenges for establishing high-fidelity BRAF V600E tumor models 4.1 The challenges of developing models for low-grade gliomas Establishing robust in vitro models that are representative of low-grade CNS tumors, incuding BRAF V600E -mutated CNS tumors is inherently challenging