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Endosomal Toll-like receptors (TLR3 and TLR7) bind to ssRNA in the endosome, while components of the inflammasome such as MDA5, RIG-I, NOD2 and PKR bind to ssRNA and dsRNA in the cytosol, resulting in cellular activation, and production of type I interferon and multiple inflammatory mediators 7 (Fig

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How the Findings Fit Together The VEGFR2, Src, FAK, ERK1/2, and FBXO22 studies were not all performed in the same cells or under the same conditions

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