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Clear therapeutic response: The dramatic improvement with B12 supplementation reinforces the diagnosis and therapeutic pathway

These habits can harm nutrient absorption

Herrmann W, Schorr H, Bodis M, Knapp JP, Muller A, Stein G, et al: Role of homocysteine, cystathionine and methylmalonic acid measurement for diagnosis of vitamin deficiency in high-aged subjects

Associated with elevated NAD+ levels and SIRT1 activation in preclinical studies [2] [3]

In neuronal senescence model studies, the active ingredient of the product can cross the blood-brain barrier (and act directly on neurons in vitro), increase NAD+ levels in nerve cells, protect mitochondrial function, reduce neuronal apoptosis, and promote the synthesis and release of neurotransmitters (such as dopamine and acetylcholine), thereby improving signal transduction in nerve cells

Some patients turn to compounded versions for affordability