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Free Radic Biol Med 52: 22542265

184 Additional uncertainties regarding the clinical relevance of the modulation of cytokine pathways by methotrexate derive from a sub-analysis of the previously described CIRT study, which showed that methotrexate treatment failed to significantly reduce the concentrations of IL-1 and IL-6 during follow-up

Elevated levels of homocysteine have been linked to increased oxidative stress, mitochondrial damage, and activation of various pathways associated with the development and progression of diabetic retinopathy

However, severe oxidative stress can overcome the capacity of the cell to reduce GSSG to GSH, leading to GSSG accumulation

Sublingual administration achieves superior absorption over 80% direct entry versus less than 10% via oral routes [17]

Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain