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Villalpando I, Lopez-Olmos V: Insulin-like growth factor I (IGF-I) regulates endocrine activity of the embryonic testis in the mouse

An increase in endogenous p62, either due to a defect in autophagy or as a result of its ectopic expression, sequesters KEAP1 into aggregates, hence causing inhibition of KEAP1-mediated NRF2 ubiquitination and degradation (43)