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Through comparative analysis of three geographically diverse gut metabolomic datasets (four case-control comparison) encompassing IBD cohorts and non-IBD controls (including patients with varying disease activity states), we identified significant pathway enrichment in aromatic amino acid metabolism, particularly involving tyrosine, phenylalanine, and tryptophan catabolism (Fig

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10.3389/fpubh.2024.1444990 86 DaiberA.FrenisK.KunticM.LiH.WolfE.KilgallenA

In addition to their involvement in the stress response, GCs (cortisol, cortisone, and corticosterone) have several essential biological functions

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10.1083/jcb.200806048 119 LacombeM.-L.Tokarska-SchlattnerM.EpandR