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Free urate crystals have considerable pro-inflammatory potential, via the ability to activate synovial lining cells and leukocytes, to induce cleavage of C5 and subsequent activation of the membrane attack complex of complement, and to trigger certain other inflammatory cascades

Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health

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Fatigue or Next-Day Sluggishness Although DSIP is employed to improve deep sleep, some people report next-day sluggishness or severe tiredness

doi: 10.1074/jbc.M609398200