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[61] Regulation by glucokinase regulatory protein Unlike hexokinases IIII, glucokinase is not inhibited by glucose 6-phosphate , that is, it is not subject to product inhibition, and continues to catalyze glucose phosphorylation even when glucose 6-phosphate accumulates

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The brain inflammatory response after CNS injury is mainly characterized by leukocyte recruitment, glial cell activation and an increase in cytokines and inflammatory factors (Simon et al., 2017)